A global analysis of community WASH access and antibiotic resistance in the human gut
On Tuesday 14 September 2021, the London School of Hygiene & Tropical Medicine organises a webinar on A global analysis of community WASH access and antibiotic resistance in the human gut, 2pm-3pm (CET).
Organiser: London School of Hygiene & Tropical Medicine
Antibiotic resistance is a growing public health issue and is likely exacerbated in settings with limited access to water, sanitation, and hygiene (WASH) infrastructure. Understanding the role of community WASH access in the proliferation of antibiotic resistance across both rural and urban communities is needed to inform public policies beyond clinical settings (e.g. stewardship).
In this talk, Erica Fuhrmeister will present her work leveraging publicly available short-read sequencing data to determine the association between community levels of improved WASH coverage and abundance of antibiotic resistance genes in human guts around the world. In total, Erica and her team compiled 1600 human stool metagenomes from 27 countries and corresponding WASH data from geospatially tagged, nationally representative household surveys. Total antibiotic resistance gene (ARG) abundance varied significantly by WHO region with the highest abundance in Africa and lowest in the Americas. Increased access to both improved drinking water and sanitation was associated with a decrease in ARG abundance in unadjusted and adjusted analyses.
The results of Erica’s primary analysis, as well as her subgroup analyses by income, WHO region, antibiotic usage in humans and livestock, urbanicity, and age will be presented. Current approaches to controlling antibiotic resistance in humans rely on antibiotic stewardship; however, this approach is difficult in low- and middle-income countries where infectious illnesses are prevalent and unregulated antibiotic usage is common. The results of this work support improved WASH infrastructure as an additional strategy to curb the spread of antibiotic resistance around the world.
Speaker: Dr. Erica Fuhrmeister
To join the webinar, please click here. There is no prior registration required.